Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population.

@article{Kamino2000DeficiencyIM,
  title={Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population.},
  author={Kouzin Kamino and Keiko Nagasaka and Masaki Imagawa and Hiromitsu Yamamoto and Hiroshi Yoneda and Akira Ueki and Shinji Kitamura and Kazuhiko Namekata and Takafumi Miki and Shigeo Ohta},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={273 1},
  pages={192-6}
}
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) deficiency is caused by a mutant allele in the Mongoloids. To examine whether genetic constitutions affecting aldehyde metabolism influence the risk for late-onset Alzheimer's disease (LOAD), we performed a case-control study in the Japanese population on the deficiency in ALDH2 caused by the dominant-negative mutant allele of the ALDH2 gene (ALDH2*2). In a comparison of 447 patients with sex, age, and region matched nondemented controls, the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China

Medical science monitor : international medical journal of experimental and clinical research • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…