Deficiency in Th2 Cytokine Responses Exacerbate Orthopoxvirus Infection

@inproceedings{Sakala2015DeficiencyIT,
  title={Deficiency in Th2 Cytokine Responses Exacerbate Orthopoxvirus Infection},
  author={Isaac G. Sakala and Geeta Chaudhri and Preethi Eldi and R. Mark L. Buller and Gunasegaran Karupiah},
  booktitle={PloS one},
  year={2015}
}
Ectromelia virus (ECTV) causes mousepox in mice, a disease very similar to smallpox in humans. ECTV and variola virus (VARV), the agent of smallpox, are closely related orthopoxviruses. Mousepox is an excellent small animal model to study the genetic and immunologic basis for resistance and susceptibility of humans to smallpox. Resistance to mousepox is dependent on a strong polarized type 1 immune response, associated with robust natural killer (NK) cell, cytotoxic T lymphocyte (CTL) and gamma… CONTINUE READING
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