Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.

@article{Akhter2004DeficiencyIS,
  title={Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.},
  author={Shamima Akhter and Christopher T. Richie and Jian Min Deng and Eric M. Brey and Xiaoshan Zhang and Charles Patrick and Richard R. Behringer and Randy J. Legerski},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 23},
  pages={10448-55}
}
Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-characterized spindle checkpoint that regulates the metaphase-to-anaphase transition. Specifically, we found that compared to wild-type cells, Snm1-deficient mouse embryonic fibroblasts exposed to… CONTINUE READING

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