Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation.

@article{PaesoldBurda2009DeficiencyIC,
  title={Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation.},
  author={Patricie Paesold-Burda and Charlotte Maag and Heinz Troxler and François Foulquier and Peter Kleinert and Siegrun Schnabel and Matthias Baumgartner and Thierry Hennet},
  journal={Human molecular genetics},
  year={2009},
  volume={18 22},
  pages={4350-6}
}
The conserved oligomeric Golgi (COG) complex is a tethering factor composed of eight subunits that is involved in the retrograde transport of intra-Golgi components. Deficient biosynthesis of COG subunits leads to alterations of protein trafficking along the secretory pathway and thereby to severe diseases in humans. Since the COG complex affects the localization of several Golgi glycosyltransferase enzymes, COG deficiency also leads to defective protein glycosylation, thereby explaining the… CONTINUE READING