Deficiency Attenuates Mouse Abdominal Aortic Aneurysm Formation

  title={Deficiency Attenuates Mouse Abdominal Aortic Aneurysm Formation},
  author={Jie Zhang and Jiusong Sun and S. Lindholt and Galina K Sukhova and Mark Sinnamon and Richard L. Stevens and Roberto Adachi and P. Scott Libby and Robert W Thompson and G P Shi},
Rationale: Mast cells (MCs) contribute to the formation of abdominal aortic aneurysms (AAAs) by producing biologically active mediators. Tryptase is the most abundant MC granule protein and participates in MC activation, protease maturation, leukocyte recruitment, and angiogenesis—all processes critical to AAA pathogenesis. Objective: To test the hypothesis that tryptase participates directly in AAA formation. Methods and Results: Immunohistochemistry demonstrated enhanced tryptase staining in… CONTINUE READING
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