Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation.

@article{Grosse2016DeficienciesOT,
  title={Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation.},
  author={Laura Grosse and Thomas A. Hoogenboezem and Oliver Ambr{\'e}e and Silja Bellingrath and Silke Joergens and Harm J de Wit and Annemarie J. M. Wijkhuijs and Volker Arolt and Hemmo A. Drexhage},
  journal={Brain, behavior, and immunity},
  year={2016},
  volume={54},
  pages={38-44}
}
BACKGROUND In a previous study, we found an up-regulated inflammatory monocyte gene expression profile in major depressive disorder (MDD) patients aged ⩾ 28 years and a down-regulated inflammatory gene expression profile in MDD patients aged<28 years. In the same sample of patients, we aimed to investigate immune dysregulation in the lymphocyte arm of the immune system, particularly in the context of the described monocyte (de-)activation states. METHODS From deep frozen leukocytes… CONTINUE READING
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