Deficiencies of clinical trials of alcohol withdrawal.

  title={Deficiencies of clinical trials of alcohol withdrawal.},
  author={G W Moskowitz and Thomas C. Chalmers and Henry S. Sacks and Richard M Fagerstrom and Helen Silver Mildred Smith},
  journal={Alcoholism, clinical and experimental research},
  volume={7 1},
Eighty-one therapeutic trials of alcohol withdrawal were found that have been published in English since 1954; controls were randomized in 29 (RCTs). Two thousand three hundred thirteen patients were randomized. Variable pretreatment description prevented estimates of delirium tremens and convulsion prevalence, but only four deaths were reported. Endpoints were thus entirely subjective in these moderately ill patients. Protocol quality of the RCTs was graded by a previously developed system for… CONTINUE READING


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