Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice

@article{Yu2010DeficienciesIT,
  title={Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice},
  author={Tao Yu and Steven J Clapcote and Zhongyou Li and Chunhong Liu and Annie Y. Pao and Allison R. Bechard and Sandra Carattini-Rivera and Sei-ichi Matsui and John C. C. Roder and Antonio Baldini and William C Mobley and Allan Bradley and Yuejin E. Yu},
  journal={Mammalian Genome},
  year={2010},
  volume={21},
  pages={258-267}
}
Copy-number variation in the human genome can be disease-causing or phenotypically neutral. This type of genetic rearrangement associated with human chromosome 21 (Hsa21) underlies partial Monosomy 21 and Trisomy 21. Mental retardation is a major clinical manifestation of partial Monosomy 21. To model this human chromosomal deletion disorder, we have generated novel mouse mutants carrying heterozygous deletions of the 2.3- and 1.1-Mb segments on mouse chromosome 10 (Mmu10) and Mmu17… CONTINUE READING

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