Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.

@article{Alexander1996DeficienciesIP,
  title={Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.},
  author={Warren S. Alexander and Andrew W Roberts and Nicos A. Nicola and Rongxiu Li and Daniel Metcalf},
  journal={Blood},
  year={1996},
  volume={87 6},
  pages={2162-70}
}
Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice developed normally but were deficient in megakaryocytes and severely thrombocytopenic. The hematocrit and numbers of mature circulating leukocytes were normal in mpl-/- mice, as was the distribution of morphologically identifiable precursors in hematopoietic tissues. Bone marrow and spleen cells of adult mpl-/- mice lacked specific binding sites for TPO, were unresponsive… CONTINUE READING

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Megakaryo - cyte growth and development factor ameliorates carboplatin - induced thrombocytopenia in mice

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