Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.

@article{Nillni2002DeficienciesIP,
  title={Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.},
  author={Eduardo A. Nillni and Weihua Xie and L. P. Mulcahy and Vanesa C Sanchez and William C. Wetsel},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 50},
  pages={48587-95}
}
Cpe(fat/fat) mice are obese, diabetic, and infertile. They have a mutation in carboxypeptidase E (CPE), an enzyme that converts prohormone intermediates to bioactive peptides. The Cpe(fat) mutation leads to rapid degradation of the enzyme. To test whether pro-thyrotropin-releasing hormone (TRH) conversion to TRH involves CPE, processing was examined in the Cpe(fat/fat) mouse. Hypothalamic TRH is depressed by at least 75% compared with wild-type controls. Concentrations of pro-TRH forms are… CONTINUE READING

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Pro-TRH Processing and Thermal Responses in Cpe Mice 48595 by gest on A uust 30

  • E. A. Nillni, C. Vaslet, M. Harris, A. Hollenberg, C. Bjorbak, J. S. Flier
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