Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease.

Abstract

Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in… (More)

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@article{Mizuno1989DeficienciesIC, title={Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease.}, author={Yuji Mizuno and Shoichiro Ohta and M. Tanaka and Shinzaburo Takamiya and Kazuo Suzuki and Toshiyuki Sato and Hiroshi Oya and Tomoko Ozawa and Yumiko Kagawa}, journal={Biochemical and biophysical research communications}, year={1989}, volume={163 3}, pages={1450-5} }