Defibrotide: A Review of Its Use in Severe Hepatic Veno-Occlusive Disease Following Haematopoietic Stem Cell Transplantation

@article{Keating2014DefibrotideAR,
  title={Defibrotide: A Review of Its Use in Severe Hepatic Veno-Occlusive Disease Following Haematopoietic Stem Cell Transplantation},
  author={Gillian M. Keating},
  journal={Clinical Drug Investigation},
  year={2014},
  volume={34},
  pages={895-904}
}
  • G. Keating
  • Published 29 October 2014
  • Medicine, Biology
  • Clinical Drug Investigation
Defibrotide (Defitelio®) was recently approved in the EU for the treatment of severe hepatic veno-occlusive disease (VOD), also known as sinusoidal obstructive syndrome, in haematopoietic stem cell transplantation (HSCT) therapy. It is indicated in adults, adolescents, children and infants over 1 month of age. Defibrotide is also available in the US via an expanded-access protocol. Defibrotide is thought to protect endothelial cells and restore the thrombo-fibrinolytic balance in VOD. In a… 
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  • Medicine
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Recommendations for prevention and principles for nursing care are presented since careful nursing monitoring, prompt intervention and care may have an influence on patients’ morbidity and mortality.
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References

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TLDR
Defibrotide, a polydisperse oligonucleotide, has been shown in phase II and III trials to improve complete response and survival in patients undergoing SCT with severe VOD.
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TLDR
Defibrotide (DF) is a polydeoxyribonucleotide with aptameric activity on endothelium that is effective in treatingeno-occlusive disease of the liver and in multivariate analysis, early intervention remained the only significant factor for a CR.
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TLDR
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TLDR
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