Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice

@inproceedings{Zhang2015DeferoxamineAL,
  title={Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice},
  author={Xiao-ying Zhang and Jiang-bei Cao and Li-ming Zhang and Yun-Feng Li and Wenli Mi},
  booktitle={Journal of Neuroinflammation},
  year={2015}
}
BackgroundNeuroinflammation often results in enduring cognitive impairment and is a risk factor for postoperative cognitive dysfunction. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that the iron chelator deferoxamine (DFO) can increase the resistance of neurons to injury and disease by stimulating adaptive cellular stress responses. However, the impact of DFO on the cognitive sequelae of neuroinflammation is unknown… CONTINUE READING

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