Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice

@inproceedings{Yan2018DeferoxamineAA,
  title={Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice},
  author={Hong-Fa Yan and Zhao-yu Liu and Zhi-Ang Guan and Chuang Guo},
  booktitle={Endocrine connections},
  year={2018}
}
OBJECTIVE The mechanisms underlying obesity and anti-obesity processes have garnered remarkable attention as potential therapeutic targets for obesity-associated metabolic syndromes. Our prior work has shown the healing efficacy of iron reduction therapies for hepatic steatosis in a rodent model of diabetes and obesity. In this study, we investigated how iron depletion by deferoxamine (DFO) affected adipocyte dysfunction in the epididymal adipose tissues of ob/ob mice. METHODS Male ob/ob mice… CONTINUE READING

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