Deferoxamine alleviates liver fibrosis induced by CCl4 in rats.

  title={Deferoxamine alleviates liver fibrosis induced by CCl4 in rats.},
  author={Aya A M Mohammed and Ekram Nemr Abd Al Haleem and Wesam M. El-Bakly and Ebtehal El-demerdash},
  journal={Clinical and experimental pharmacology & physiology},
  volume={43 8},
Several chronic liver diseases can lead to the occurrence of hepatic fibrosis through the accumulation of iron, which causes induction of oxidative stress and consequently activation of fibrogenesis. The present study was designed to investigate the potential antifibrotic and anti-oxidant effects of deferoxamine (DFO), a well-known iron chelator in an experimental rat model of liver injury using carbon tetrachloride (CCl4 ). First, the potential effective dose of DFO was screened against CCl4… CONTINUE READING