Deferasirox for transfusion-related iron overload: a clinical review.

@article{Lindsey2007DeferasiroxFT,
  title={Deferasirox for transfusion-related iron overload: a clinical review.},
  author={Wesley T. Lindsey and Bernie R. Olin},
  journal={Clinical therapeutics},
  year={2007},
  volume={29 10},
  pages={
          2154-66
        }
}
BACKGROUND Iron is an essential element involved in energy production, mitochondrial respiration, and DNA synthesis in the body. Excess iron forms insoluble complexes that are deposited in, and cause damage to, internal organs. Diseases such as beta-thalassemia and myelodysplastic syndrome that require frequent blood transfusions can result in excess iron in the body. The traditional therapy for iron overload is overnight infusion of deferoxamine multiple nights per week. Deferasirox is a new… CONTINUE READING

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