Deferasirox--current knowledge and future challenges.

@article{Porter2010DeferasiroxcurrentKA,
  title={Deferasirox--current knowledge and future challenges.},
  author={John B. Porter},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1202},
  pages={
          87-93
        }
}
Since the last Cooley's symposium in 2005, our knowledge and clinical experience with deferasirox had advanced considerably. This has been based on prospective multicenter clinical trials, on a scale hitherto unprecedented for chelation therapy, now totalling over 7,400 patients. Here, current knowledge about the clinical effects of deferasirox is described in key areas, namely, the pharmacokinetics and its relevance to mechanisms of action; effects on iron balance; effects on serum ferritin… CONTINUE READING
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