Defensins in innate antiviral immunity

@article{Klotman2006DefensinsII,
  title={Defensins in innate antiviral immunity},
  author={Mary E. Klotman and Theresa L. Chang},
  journal={Nature Reviews Immunology},
  year={2006},
  volume={6},
  pages={447-456}
}
Defensins are small antimicrobial peptides that are produced by leukocytes and epithelial cells, and that have an important role in innate immunity. Recent advances in understanding the mechanisms of the antiviral action(s) of defensins indicate that they have a dual role in antiviral defence, acting directly on the virion and on the host cell. This Review focuses on the antiviral activities and mechanisms of action of mammalian defensins, and on the clinical relevance of these activities… 
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TLDR
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Antiviral Mechanisms of Human Defensins
The roles of antimicrobial peptides in innate host defense.
TLDR
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Function of Antimicrobial Peptides in Lung Innate Immunity
TLDR
The innate immune system of the lung is a complex network of different cellular and noncellular components protecting the lung from inhaled pathogens that include modulation of the innate and adaptive immune response to infection as well as lung repair after injury.
Defensins: A Double-Edged Sword in Host Immunity
TLDR
It is posited that given an enabling environment defensins, widely heralded as the “Swiss army knife,” can function as a “double−edged sword” in host immunity.
Towards the Application of Human Defensins as Antivirals
TLDR
It is suggested that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus, influenza A virus, respiratory syncytial virus, and dengue virus, which have posed huge challenges for vaccine development for different reasons.
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