Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.

@article{McDermott2003DefensinEB,
  title={Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.},
  author={Alison Marie McDermott and Rachel L. Redfern and Bei Zhang and Ying Pei and Ling Huang and Rita J. Proske},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 5},
  pages={1859-65}
}
PURPOSE To investigate the expression of human beta-defensins (hBDs) by human corneal epithelium and determine the effects of proinflammatory cytokines on expression of human beta-defensin (hBD)-2 by human corneal epithelial cells (HCECs) in culture. METHODS RNA was extracted from corneal epithelial cells scraped from cadaveric corneas and from cultured HCECs, and RT-PCR was performed to detect hBD-1, -2, and -3 mRNA. To study the effects of proinflammatory cytokines on expression of defensin… CONTINUE READING