Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel.

@article{Jones1993Defensin6MI,
  title={Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel.},
  author={Douglas Elliot Jones and Charles L. Bevins},
  journal={FEBS letters},
  year={1993},
  volume={315 2},
  pages={187-92}
}
The epithelial surface of the human small intestine is a barrier between the host and the microbial environment of the lumen. A human small intestine cDNA clone was found to encode a new member of the defensin family of antimicrobial peptides, named human defensin-6. Tissue expression of this mRNA is specific for the small intestine as determined by Northern blot analysis and polymerase chain reaction analysis. In situ hybridization demonstrated that human defensin-6 mRNA localizes to Paneth… CONTINUE READING