Defense mechanisms of IFN-gamma and LPS-primed murine microglia against Acanthamoeba castellanii infection.

@article{Benedetto2003DefenseMO,
  title={Defense mechanisms of IFN-gamma and LPS-primed murine microglia against Acanthamoeba castellanii infection.},
  author={Nunzia Benedetto and Fabio Rossano and Fernanda Gorga and A. Folgore and Meghana Rao and Caterina Romano Carratelli},
  journal={International immunopharmacology},
  year={2003},
  volume={3 6},
  pages={825-34}
}
In the central nervous system (CNS), cytokine-primed microglia play a central role in host's defense against Acanthamoeba castellanii infection. In this study, the effect of recombinant interferon (rIFN)-gamma and Salmonella enterica serovar enteritidis lipopolysaccharide (LPS), both inflammatory stimuli, on A. castellanii infection in murine microglia was examined. Priming of microglia with rIFN-gamma and LPS synergistically triggered, in a dose-dependent manner, amebastatic activity in these… CONTINUE READING