• Corpus ID: 28562978

Defense mechanisms against influenza virus infection in the respiratory tract mucosa.

@article{Tamura2004DefenseMA,
  title={Defense mechanisms against influenza virus infection in the respiratory tract mucosa.},
  author={Shin‐ichi Tamura and Takeshi Kurata},
  journal={Japanese journal of infectious diseases},
  year={2004},
  volume={57 6},
  pages={
          236-47
        }
}
  • S. Tamura, T. Kurata
  • Published 1 December 2004
  • Biology
  • Japanese journal of infectious diseases
The respiratory tract mucosa is not only the site of infection for influenza viruses but also the site of defense against virus infection. [] Key Result The IgG Abs, which transude from the serum to the mucus by diffusion, provide protection against homologous virus infection. They are largely distributed on the alveolar epithelia to prevent influenza pneumonia.

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References

SHOWING 1-10 OF 125 REFERENCES

Passive transfer of local immunity to influenza virus infection by IgA antibody.

TLDR
The passive transfer of local immunity by the i.v. administration of pIgA antibody is demonstrated and it is shown that the IgA in secretions can protect against influenza virus infection.

Secretory anti-influenza immunity.

The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice

TLDR
Observations reveal no significant contribution for IFN-controlled pathways in shaping acute or memory T-cell responses to pneumotropic influenza virus infection but do indicate some role forIFN-α/β in the regulation of antibody responses.

Gamma Interferon Is Not Required for Mucosal Cytotoxic T-Lymphocyte Responses or Heterosubtypic Immunity to Influenza A Virus Infection in Mice

TLDR
It is conclusively show that IFN-γ is not required for induction of secondary influenza virus-specific CTL responses in mediastinal lymph nodes and HSI to lethal influenza A virus infection.

Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus

TLDR
This report shows that adoptive transfer of primary or secondary immune spleen cells to mice inoculated intranasally with a lethal dose of A/WSN virus caused a significant reduction of infectious virus levels in the lungs and prevented death.

Defense mechanisms against primary influenza virus infection in mice. I. The roles of interferon and neutralizing antibodies and thymus dependence of interferon and antibody production.

TLDR
It is suggested thatinterferon plays an important role in the transition from the first phase to the second, and that T cells are required for interferon induction in mice infected with influenza virus.

Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection.

TLDR
In parallel with the detection of AFCs in infected mice, virus-specific IgA antibodies appeared in the nasal wash and their appearance correlated well with virus clearance from the nasal area, suggesting that virus- specific IgA proteins play an important role in recovery from infection.

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

TLDR
A virus-specific Tc cell response is not a requirement for recovery from a pulmonary influenza virus infection, compatible with virus clearance being effected either directly after recognition of infected class II-positive cells by the transferred Th cells or indirectly via promotion of a glycoprotein-specific antibody response.

Heterosubtypic Immunity to Influenza A Virus in Mice Lacking IgA, All Ig, NKT Cells, or γδ T Cells1

TLDR
The results in Ig−/− mice indicate that CD4+ T cells can function by mechanisms other than providing help to B cells for the generation of Abs, and demonstrate that each may play a role in a multifaceted response that as a whole is more effective than any of its parts.
...