Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

Abstract

Methylglyoxal is a dicarbonyl compound that acts as a toxic electrophile in biological systems. Methylglyoxal is produced in certain bacteria as a byproduct of glycolysis through methylglyoxal synthase. Like many bacteria, Group A Streptococcus (GAS), a Gram-positive human pathogen responsible for a wide spectrum of diseases, uses a two-step glyoxalase… (More)
DOI: 10.1093/femspd/ftv122

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Cite this paper

@article{Zhang2016DefenceAM, title={Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?}, author={May M Zhang and Cheryl-lynn Y. Ong and Mark J. Walker and Alastair G. McEwan}, journal={Pathogens and disease}, year={2016}, volume={74 2} }