Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL).

@article{Lowsky1997DefectsOT,
  title={Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL).},
  author={Robert J Lowsky and John F Decoteau and Armin H Reitmair and Ryo Ichinohasama and Wei F Dong and Yinyan Xu and Tak W Mak and Marshall Edward Kadin and Mark D Minden},
  journal={Blood},
  year={1997},
  volume={89 7},
  pages={2276-82}
}
Mutations in the DNA mismatch repair (MMR) gene hMSH2 underlie a novel pathway of tumorigenesis for some cancers of epithelial origin. Mice deficient in MSH2 are susceptible to lymphomas but defects in this gene have not been identified in human lymphoid tumors. To determine if the lymphomas these mice develop are related to a particular subtype of human lymphoma we evaluated 20 clinically ill homozygous MSH2-/- mice ranging in age from 2 to 13 months. The murine tumors comprised a single… CONTINUE READING
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