Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.

@article{Kinder2001DefectsOT,
  title={Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.},
  author={Simon J. Kinder and Tania E Tsang and Sharyn L Ang and Richard R. Behringer and Patrick P. L. Tam},
  journal={The International journal of developmental biology},
  year={2001},
  volume={45 1},
  pages={347-55}
}
The orientation of the anterior-posterior (A-P) axis was examined in gastrula-stage Hnf3beta, Otx2 and Lim1 null mutant embryos that display defective axis development. In situ hybridization analysis of the expression pattern of genes associated with the posterior germ layer tissues and the primitive streak (T, Wnt3 and Fgf8) and anterior endoderm (Cer1 and Sox17) revealed that the A-P axis of mutant embryos remains aligned with the proximo-distal plane of the gastrula. Further analysis… CONTINUE READING

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