Defects in trophoblast cell lineage account for the impaired in vivo development of cloned embryos generated by somatic nuclear transfer.

@article{Lin2011DefectsIT,
  title={Defects in trophoblast cell lineage account for the impaired in vivo development of cloned embryos generated by somatic nuclear transfer.},
  author={Jiangwei Lin and Linyu Shi and Man Zhang and Hui Yang and Yiren Qin and Jun Yu Zhang and Daoqing Gong and Xuan Zhang and Dangsheng Li and Jinsong Li},
  journal={Cell stem cell},
  year={2011},
  volume={8 4},
  pages={371-5}
}
The low success rate of somatic nuclear transfer (NT) is hypothesized to be mainly due to functional defects in the trophoblast cell lineage rather than the inner cell mass (ICM); this hypothesis, however, remains to be tested directly. Here we separated the ICMs from cloned blastocysts and aggregated the cloned ICM with two fertilization-derived (FD) tetraploid (4N) embryos. We found that the full-term development of cloned ICMs was dramatically improved after the trophoblast cells in the… CONTINUE READING

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