Defects in polynucleotide phosphorylase impairs virulence in Escherichia coli O157:H7

@inproceedings{Hu2015DefectsIP,
  title={Defects in polynucleotide phosphorylase impairs virulence in Escherichia coli O157:H7},
  author={Jia Qi Hu and Mei-Jun Zhu},
  booktitle={Front. Microbiol.},
  year={2015}
}
Polynucleotide phosphorylase (PNPase) is reported to regulate virulence in Salmonella, Yersinia sp. and Campylobacter jejuni, yet its role in Escherichia coli O157:H7 has not been investigated. To gain insights into its roles in E. coli O157:H7 virulence, pnp deletion mutants were generated and the major virulence factors were compared to their parental wild type strains. Deletion of pnp in E. coli O157:H7 dramatically decreased stx2 mRNA expression and Stx2 protein production, and impaired… CONTINUE READING
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