Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice.

Abstract

Laminopathies are a group of disorders caused by mutations in the LMNA gene that encodes the nuclear lamina proteins, lamin A and lamin C; their pathophysiological basis is unknown. We report that lamin A/C-deficient (Lmna(-/-)) mice develop rapidly progressive dilated cardiomyopathy (DCM) characterized by left ventricular (LV) dilation and reduced systolic… (More)

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Cite this paper

@article{Nikolova2004DefectsIN, title={Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice.}, author={Vesna Nikolova and Christiana Leimena and Aisling Mcmahon and Ju Chiat Tan and Suchitra Chandar and Dilesh M Jogia and Scott H. Kesteven and Jan Michalicek and Robyn T. Otway and Fons K C P Verheyen and Stephen P. Rainer and Colin Lawson Stewart and David Martin and Michael Feneley and Diane Fatkin}, journal={The Journal of clinical investigation}, year={2004}, volume={113 3}, pages={357-69} }