Defects in mucosal immunity leading to Crohn's disease

@article{Cobrin2005DefectsIM,
  title={Defects in mucosal immunity leading to Crohn's disease},
  author={Gena M Cobrin and Maria T. Abreu},
  journal={Immunological Reviews},
  year={2005},
  volume={206}
}
Summary:  Crohn's disease (CD) is characterized by patchy transmural inflammation involving any part of the intestinal tract. Animal models have provided a great deal of insight into the pathogenesis of CD, but no animal model has recapitulated the full spectrum of manifestations witnessed in human disease. The defects in mucosal immunity in CD can be divided into those that involve the epithelial barrier, those that involve the innate immune response, and finally, defects in the adaptive… 
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