Defects in mucosal immunity leading to Crohn's disease

@article{Cobrin2005DefectsIM,
  title={Defects in mucosal immunity leading to Crohn's disease},
  author={Gena M Cobrin and M. Abreu},
  journal={Immunological Reviews},
  year={2005},
  volume={206}
}
Summary:  Crohn's disease (CD) is characterized by patchy transmural inflammation involving any part of the intestinal tract. Animal models have provided a great deal of insight into the pathogenesis of CD, but no animal model has recapitulated the full spectrum of manifestations witnessed in human disease. The defects in mucosal immunity in CD can be divided into those that involve the epithelial barrier, those that involve the innate immune response, and finally, defects in the adaptive… Expand
Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's disease?
Mechanisms of Microbe–Host Interaction in Crohn’s Disease: Dysbiosis vs. Pathobiont Selection
Inflammatory bowel disease: clinical aspects and treatments
IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 243 REFERENCES
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease.
Update in inflammatory bowel disease pathogenesis
  • G. Rogler
  • Biology, Medicine
  • Current opinion in gastroenterology
  • 2004
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation.
Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
The immunology of mucosal models of inflammation.
...
1
2
3
4
5
...