Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS).

  title={Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS).},
  author={Andrea Dunaif and Xiaobin Wu and Andrew Go Lee and Evanthia Diamanti-Kandarakis},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={281 2},
Women with polycystic ovary syndrome (PCOS) are insulin resistant secondary to a postbinding defect in insulin signaling. Sequential euglycemic glucose clamp studies at 40 and 400 mU. m(-2). min(-1) insulin doses with serial skeletal muscle biopsies were performed in PCOS and age-, weight-, and ethnicity-matched control women. Steady-state insulin levels did not differ, but insulin-mediated glucose disposal was significantly decreased in PCOS women (P < 0.05). Insulin receptor substrate (IRS)-1… CONTINUE READING


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