Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI.

@article{Rivero2002DefectsIC,
  title={Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI.},
  author={Francisco Rivero and Daria Illenberger and Baggavalli P. Somesh and Heidrun Dislich and Nicola Adam and A. Meyer},
  journal={The EMBO journal},
  year={2002},
  volume={21 17},
  pages={4539-49}
}
Rho GDP-dissociation inhibitors (RhoGDIs) modulate the cycling of Rho GTPases between active GTP-bound and inactive GDP-bound states. We identified two RhoGDI homologues in DICTYOSTELIUM: GDI1 shares 51-58% similarity to RhoGDIs from diverse species. GDI2 is more divergent (40-44% similarity) and lacks the N-terminal regulatory arm characteristic for RhoGDI proteins. Both are cytosolic proteins and do not relocalize upon reorganization of the actin cytoskeleton. Using a two-hybrid approach, we… CONTINUE READING

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