Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.

Abstract

Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pompe disease, mitochondrial function has escaped examination in this typical LSD. We have found multiple mitochondrial defects in mouse and human models of Pompe… (More)
DOI: 10.1080/15548627.2015.1009779

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Cite this paper

@article{Lim2015DefectsIC, title={Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.}, author={Jeong-A Lim and Lishu Li and Or Kakhlon and Rachel Myerowitz and Nina Raben}, journal={Autophagy}, year={2015}, volume={11 2}, pages={385-402} }