Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice.

@article{ValverdeFranco2006DefectsIA,
  title={Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice.},
  author={Gladys Valverde-Franco and J S Binette and Wei Li and Haiyan Wang and Sen Chai and F Laflamme and Nicolas Tran-Khanh and Eric Quenneville and Tineke Meijers and A. Robin Poole and John S. Mort and Michael D. Buschmann and Janet E Henderson},
  journal={Human molecular genetics},
  year={2006},
  volume={15 11},
  pages={1783-92}
}
Fibroblast growth factor (FGF) receptor 3 has been identified as a key regulator of endochondral bone development and of post-natal bone metabolism through its action on growth plate chondrocytes and osteoblasts, respectively. It has also been shown to promote chondrogenesis and cartilage production by cultured pre-chondrogenic cells in response to FGF18. In the current studies, we show that the absence of signaling through Fgfr3 in the joints of Fgfr3(-/-) mice leads to premature cartilage… CONTINUE READING
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