Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans results in acid sensitivity.

@article{Boyd2000DefectsID,
  title={Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans results in acid sensitivity.},
  author={David A K Boyd and Dennis Gerard Cvitkovitch and Arnold S. Bleiweis and Michael Y. Kiriukhin and Dmitri V Debabov and Francis C Neuhaus and Ian R. Hamilton},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 21},
  pages={6055-65}
}
In the cariogenic organism, Streptococcus mutans, low pH induces an acid tolerance response (ATR). To identify acid-regulated proteins comprising the ATR, transposon mutagenesis with the thermosensitive plasmid pGh9:ISS1 was used to produce clones that were able to grow at neutral pH, but not in medium at pH 5.0. Sequence analysis of one mutant (IS1A) indicated that transposition had created a 6.3-kb deletion, one end of which was in dltB of the dlt operon encoding four proteins (DltA-DltD… CONTINUE READING
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