Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis.

@article{FloresBorja2008DefectsIC,
  title={Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis.},
  author={Fabian Flores-Borja and Elizabeth C. Jury and C Mauri and Michael R. Ehrenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 49},
  pages={19396-401}
}
The ultimate goal for the treatment of autoimmunity is to restore immunological tolerance. Regulatory T cells (Treg) play a central role in immune tolerance, and Treg functional abnormalities have been identified in different autoimmune diseases, including rheumatoid arthritis (RA). We have previously shown that natural Treg from RA patients are competent at suppressing responder T cell proliferation but not cytokine production. Here, we explore the hypothesis that this Treg defect in RA is… CONTINUE READING
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