Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3.

@article{Thomis1995DefectsIB,
  title={Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3.},
  author={Daniel C. Thomis and Christine B. Gurniak and Elizabeth A. Tivol and Arlene H Sharpe and Leslie J Berg},
  journal={Science},
  year={1995},
  volume={270 5237},
  pages={794-7}
}
Biochemical studies of signaling mediated by many cytokine and growth factor receptors have implicated members of the Jak family of tyrosine kinases in these pathways. Specifically, Jak3 has been shown to be associated with the interleukin-2 (IL-2) receptor gamma chain, a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Mice lacking Jak3 showed a severe block in B cell development at the pre-B stage in the bone marrow. In contrast, although the thymuses of these mice were small… CONTINUE READING

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