Defects in 18 S or 28 S rRNA processing activate the p53 pathway.

@article{Hlzel2010DefectsI1,
  title={Defects in 18 S or 28 S rRNA processing activate the p53 pathway.},
  author={Michael H{\"o}lzel and Mathias Orban and Julia Hochstatter and Michaela Rohrmoser and Thomas Harasim and Anastassia Malamoussi and Elisabeth Kremmer and Gernot L{\"a}ngst and Dirk Eick},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 9},
  pages={6364-70}
}
The p53 tumor suppressor pathway is activated by defective ribosome synthesis. Ribosomal proteins are released from the nucleolus and block human double minute-2 (Hdm2) that targets p53 for degradation. However, it remained elusive how abrogation of individual rRNA processing pathways contributes to p53 stabilization. Here, we show that selective inhibition of 18 S rRNA processing provokes accumulation of p53 as efficiently as abrogated 28 S rRNA maturation. We describe hUTP18 as a novel… CONTINUE READING

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Inhibition Activates p53 6370 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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