Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis.

@article{Finzi2006DefectiveVD,
  title={Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis.},
  author={Diana Finzi and Susan F. Plaeger and Carl W. Dieffenbach},
  journal={Clinical and vaccine immunology : CVI},
  year={2006},
  volume={13 7},
  pages={715-21}
}
Many aspects of the human immunodeficiency virus (HIV) life cycle are well understood, yet a key paradox remains. The primary targets for HIV are resting CD4 T lymphocytes that are not permissive to HIV replication unless activated by some external and independent event. Numerous mechanisms for this essential cellular activation step have been proposed, including coinfections, vaccination, cytokines, and endogenous microbial flora. We propose that a review of the scientific evidence reveals a… CONTINUE READING

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