Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.

@article{Jackson2003DefectiveVI,
  title={Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.},
  author={Leslie F. Jackson and Ting Hu Qiu and Susan Wohler Sunnarborg and Aileen Y Chang and Chunlian Zhang and C. G. Patterson and David C. Lee},
  journal={The EMBO journal},
  year={2003},
  volume={22 11},
  pages={2704-16}
}
Heparin-binding epidermal growth factor (HB-EGF) and betacellulin (BTC) are activating ligands for EGF receptor (EGFR/ErbB1) and ErbB4. To identify their physiological functions, we disrupted mouse HB-EGF and BTC alleles by homologous recombination. Most HB-EGF(-/-) mice died before weaning, and survivors had enlarged, dysfunctional hearts and reduced lifespans. Although BTC(-/-) mice were viable and fertile and displayed no overt defects, the lifespan of double null HB-EGF(-/-)/BTC(-/-) mice… CONTINUE READING
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