Defective tumoricidal capacity of macrophages from C3H/HeJ mice.

@article{Ruco1978DefectiveTC,
  title={Defective tumoricidal capacity of macrophages from C3H/HeJ mice.},
  author={Luigi P. Ruco and Monte S. Meltzer},
  journal={Journal of immunology},
  year={1978},
  volume={120 1},
  pages={329-34}
}
Peritoneal macrophages from C3H/HeN mice treated i.p. with T cell mitogens or viable BCG organisms were cytotoxic to syngeneic tumor cells in vitro. Macrophages from endotoxin-unresponsive C3H/HeJ mice treated with BCG or T cell mitogens, however, were not tumoricidal. Furthermore, unlike cells from C3H/HeN mice, macrophages from C3H/HeJ mice could not be activated for tumor cytotoxicity after in vitro treatment with bacterial endotoxins or with lymphokine-rich supernatants. The subnormal… CONTINUE READING

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