Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

  title={Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease},
  author={Luigina Romani and Francesca Fallarino and Antonella de Luca and Claudia Montagnoli and Carmen D’Angelo and Teresa Zelante and Carmine Vacca and Francesco Bistoni and Maria Cristina Fioretti and Ursula Grohmann and Brahm H. Segal and Paolo Puccetti},
Half a century ago, chronic granulomatous disease (CGD) was first described as a disease fatally affecting the ability of children to survive infections. Various milestone discoveries have since been made, from an insufficient ability of patients’ leucocytes to kill microbes to the underlying genetic abnormalities. In this inherited disorder, phagocytes lack NADPH oxidase activity and do not generate reactive oxygen species, most notably superoxide anion, causing recurrent bacterial and fungal… CONTINUE READING
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