Defective trophoblast function in mice with a targeted mutation of Ets2.

  title={Defective trophoblast function in mice with a targeted mutation of Ets2.},
  author={Hiroyuki Yamamoto and M. L. Flannery and Sergey Kupriyanov and James W. Pearce and Scott R Mckercher and Gregory W. Henkel and Richard A Maki and Zena Werb and Robert G. Oshima},
  journal={Genes & development},
  volume={12 9},
Members of the Ets family of transcription factors mediate transcriptional responses of multiple signaling pathways in diverse cell types and organisms. Targeted deletion of the conserved DNA binding domain of the Ets2 transcription factor results in the retardation and death of homozygous mouse embryos before 8.5 days of embryonic development. Defects in extraembryonic tissue gene expression and function include deficient expression of matrix metalloproteinase-9 (MMP-9, gelatinase B… CONTINUE READING
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