Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo.

@article{Schallreuter1994DefectiveTA,
  title={Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo.},
  author={Karin Uta Schallreuter and John P. M. Wood and Irmgard Ziegler and K. Regina Lemke and Mark R. Pittelkow and Nigel J Lindsey and Markus G{\"u}tlich},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1226 2},
  pages={181-92}
}
Patients with the depigmentation disorder vitiligo lack the capacity to synthesize the melanins from L-tyrosine via the essential activity of tyrosinase. The aim of this study has been to examine both the supply of the substrate (L-tyrosine) and the regulation of tyrosinase in the epidermis of subjects with vitiligo. Patients with this depigmentation disorder have a 3- to 5-fold increase in GTP-cyclohydrolase I activity leading to an excessive de novo synthesis of (6R)5,6,7,8… CONTINUE READING
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