Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin–Lowry syndrome
@article{Morice2013DefectiveST, title={Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin–Lowry syndrome}, author={Elise Morice and S{\'e}verine Farley and Roseline Poirier and Glenn Dall{\'e}rac and Carine Chagneau and Solange Pannetier and André Hanauer and Sabrina Davis and Cyrille Vaillend and Serge Laroche}, journal={Neurobiology of Disease}, year={2013}, volume={58}, pages={156-168} }
27 Citations
Selective alteration of adult hippocampal neurogenesis and impaired spatial pattern separation performance in the RSK2-deficient mouse model of Coffin-Lowry syndrome
- Biology, PsychologyNeurobiology of Disease
- 2018
Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.
- BiologyBiochimica et biophysica acta
- 2016
NMDA receptor‐deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities
- Psychology, BiologyGenes, brain, and behavior
- 2014
It is found that while juvenile mutant mice had some ability to problem solve in the puzzle box test, the same mice lost this ability when tested 4 weeks later, and executive function was most impaired in peri‐adolescent mice of either sex.
DMM021246 1389..1400
- Biology
- 2015
It is concluded that RSK is required for normal synaptic morphology and function and loss of RSK function interferes with ERK signaling at different levels, which emphasizes the importance of fine-tuning ERK activity in neuronal processes underlying higher brain functions.
Role of p90 ribosomal S6 kinase in long-term synaptic facilitation and enhanced neuronal excitability
- BiologyScientific Reports
- 2020
Inhibition of RSK expression or RSK activity both significantly reduced CREB1 phosphorylation, LTF, and LTEE, suggesting RSK is required for learning-related synaptic plasticity and enhancement in neuronal excitability.
Defective synaptic plasticity in a model of Coffin-Lowry Syndrome is rescued by simultaneously targeting PKA and MAPK pathways
- Biology, ChemistrybioRxiv
- 2022
Examination of whether individual or dual-drug treatments can restore the deficit in long-term synaptic facilitation of the Aplysia sensorimotor synapse observed in a molecular model of Coffin-Lowry Syndrome found that the combined drugs exerted synergistic effects on both RSK activation and LTF, fully restoring RSK phosphorylation and L TF.
Rsk2 Knockout Affects Emotional Behavior in the IntelliCage
- Biology, PsychologyBehavior genetics
- 2017
Taken together, RSK2 not only plays a role in cognitive processes but also in emotional and reward-related behaviors.
Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction
- BiologyFront. Behav. Neurosci.
- 2018
Understanding of the pathophysiology of CLS can be improved, which might open the door for development of potential intervention strategies, and some common aspects of RSK2 function in the nervous system have emerged.
PPARγ Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement
- BiologyThe Journal of Neuroscience
- 2014
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