Defective specific antiinfluenza virus antibody production in vitro by lymphocytes from patients with ataxia-telangiectasia.


The ability of lymphocytes from 11 patients with ataxia-telangiectasia to produce specific antiinfluenza virus antibody in vitro was evaluated. Lymphocytes from these patients produced markedly less antibody than lymphocytes from normal controls when stimulated with type A influenza viruses. Additional studies were undertaken to evaluate the function of the… (More)


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