Defective somite patterning in mouse embryos with reduced levels of Tbx6.

@article{White2003DefectiveSP,
  title={Defective somite patterning in mouse embryos with reduced levels of Tbx6.},
  author={Phillip H White and Deborah R Farkas and Erin E McFadden and Deborah L. Chapman},
  journal={Development},
  year={2003},
  volume={130 8},
  pages={1681-90}
}
During vertebrate embryogenesis, paraxial mesoderm gives rise to somites, which subsequently develop into the dermis, skeletal muscle, ribs and vertebrae of the adult. Mutations that disrupt the patterning of individual somites have dramatic effects on these tissues, including fusions of the ribs and vertebrae. The T-box transcription factor, Tbx6, is expressed in the paraxial mesoderm but is downregulated as somites develop. It is essential for the formation of posterior somites, which are… CONTINUE READING
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