Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast

@inproceedings{Sanchez2017DefectiveRI,
  title={Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast},
  author={Joseph C. Sanchez and Elizabeth X. Kwan and Thomas J Pohl and Haley M Amemiya and M. K. Raghuraman and Bonita J. Brewer},
  booktitle={PLoS genetics},
  year={2017}
}
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5). These genes encode components of the pre-replication complex, which assembles at origins of replication prior to S phase. Also, variants in two additional replication initiation genes have joined… CONTINUE READING