Defective renal dopamine D1-like receptor signal transduction in obese hypertensive rats.

@article{Lokhandwala2000DefectiveRD,
  title={Defective renal dopamine D1-like receptor signal transduction in obese hypertensive rats.},
  author={Mustafa Lokhandwala and Tahir Hussain},
  journal={Acta physiologica Scandinavica},
  year={2000},
  volume={168 1},
  pages={
          251-5
        }
}
It is reported that dopamine promotes renal sodium excretion via activation of D1-like dopamine receptors located on the proximal tubules. In spontaneously hypertensive rats the natriuretic and diuretic response to exogenously administered and endogenously produced dopamine is reduced, which results from a diminished dopamine-induced inhibition of the enzyme, Na+,K+-ATPase. The present study was designed to examine dopamine-receptor mediated inhibition of Na+,K+-ATPase and its associated signal… CONTINUE READING
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