Defective renal calcium reabsorption in genetic hypercalciuric rats.

@article{Tsuruoka1997DefectiveRC,
  title={Defective renal calcium reabsorption in genetic hypercalciuric rats.},
  author={Shuichi Tsuruoka and David A. Bushinsky and George J. Schwartz},
  journal={Kidney international},
  year={1997},
  volume={51 5},
  pages={1540-7}
}
Idiopathic hypercalciuria is a frequent cause of calcium (Ca) containing kidney stones. We have previously shown that there is increased intestinal Ca absorption in selectively inbred genetic hypercalciuric stone forming (GHS) rats; however, excess Ca excretion persists when the rats are fed a low Ca diet indicating a defect in renal Ca reabsorption and/or increased bone resorption. To determine if GHS rats have a defect in renal Ca reabsorption we performed 14C-inulin clearance studies on… CONTINUE READING
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