Defective production of interleukin-11 by decidua and chorionic villi in human anembryonic pregnancy.

@article{Chen2002DefectivePO,
  title={Defective production of interleukin-11 by decidua and chorionic villi in human anembryonic pregnancy.},
  author={H. F. Chen and Ching-Yin Lin and K C Chao and Ming-Yih Wu and Y Yang and Hong-Nerng Ho},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 5},
  pages={2320-8}
}
Previous study demonstrated that IL-11 receptor alpha knockout female mice (IL-11Ralpha(-/-)) were phenotypically normal but infertile due to defective decidualization. However, the role of IL-11 signaling in human reproduction remains unclear. This study examined the expression of IL-11, IL-11Ralpha, and signal transduction factor glycoprotein 130 in different phases of endometrium (six in proliferative phase and four in secretory phase), and the decidua and villi of normal pregnancy (NP; n… CONTINUE READING
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